Description
Product Characteristics: Netrin-4 is a 628 amino acid laminin-related secreted protein that promotes neurite elongation at low concentrations but inhibits neurite extension at high concentrations. Recent evidence suggest that Netrin family members act as regulators of both neuronal and vascular growth and are implicated in controling epithelial cell branching morphogenesis in the pancreas, breast and lung. Netrin-4 inhibits proliferation of a variety of human tumor cells. Netrin-4 also induces proliferation, migration, adhesion, tube formation and survival of human lymphatic endothelial cells and seems to function as a lymphangiogenic factor contributing to tumor dissemination.
Target Information: NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008]